In 1966 with her vision of the exact dates for a great Chicago blizzard, Irene Hughes soon became known widely as the "Chicago Seeress." She has foretold deaths, assassinations, marriages, divorces, winning teams in sports, major weather disasters, and the outcome of elections. Notarized statements, personal letters of affirmation, and newspaper records, have validated her predictions. She has predicted the following: In 1966, the Middle Eastern War of June 1967; in January 1967 President Lyndon B. Johnson (1908–1973) would not seek another term, which he announced in April of that year; in November 1967,the assassination of Robert Kennedy (1925–1968), which occurred in June 1968; in 1969, a "tragedy for Senator Kennedy, in or around water" prior to Edward "Ted" Kennedy's (1932– ) crisis at Chappaquidick when the automobile that he was driving went into the water, drowning one of his campaign workers. In 1987 she published her prediction of a plummeting stock market and told a group of millionaires that the market would drop "400 points" on the following Monday. On "Black Monday," the market dropped 500 points. Two weeks before Princess Diana's (1961–1997) death in 1997, Hughes told her radio audience that the princess was in a death cycle and that her death would occur soon.
An area in which she has devoted particular attention has been that of offering psychic assistance to criminal investigators. In all cases, the police solicited Hughes's help.
Hughes's experience with the law and her own research into all phases of psychic phenomena has given her time to give thought to the matter of psychics and possible legal conflicts. "It should be stressed that the information a psychic gives to police officers should be for their use alone to check out and turn into factual evidence," she said. "No psychic information should ever be used in court without the police having first checked it out and proved it to be accurate."